Running through portions of Franklin and Somerset counties, it connects SR 43 in the town of Industry with Madison at U.S. Route 201 (US 201).

The road heads north mostly through forested areas though it skirts the easterly edges of small hills and passes to the east of Clearwater Pond.

After passing a small farm with numerous work buildings, SR 148 makes a 90-degree bend to head east to the settlement of West Mills.

It continues traveling through mostly wooded areas before reaching the settlement of Five Points where it intersects and forms a concurrency with SR 43 towards downtown Anson.

The two routes enter the more urbanized area of Anson on Main Street passing a post office and the town hall before curving to the north at Kennebec River.