Between 1930 and 1945, Bischofsheim was a district of the city of Mainz and, as a result, the station was renamed Mainz-Bischofsheim.

The Prussian-Hessian Railway Company created a hub of national significance at Bischofsheim.

The old station building at the water tower (both of which are listed as monuments under the Hessian heritage law[5]) was now used for handling freight.

Bischofsheim lies in the area served by the Rhein-Main-Verkehrsverbund (Rhine-Main Transport Association, RMV).

Bischofsheim station is served by the Mittelrhein-Main-Express RE 2 service running between Koblenz Hauptbahnhof and Frankfurt every two hours.