Major League Baseball 2K8 Fantasy All-Stars is the Nintendo DS spin-off of Major League Baseball 2K8 in the vein of MLB Power Pros, developed by Canadian studio Deep Fried Entertainment and published by 2K Sports.

The game extensively utilizes the Nintendo DS touchscreen, which controls the power and technique of bat swings and the speed and accuracy of pitches.

Fielding, baserunning and other controls will also utilize the DS touch screen, by dragging and tracing lines to execute those baseball actions.

Power up pitches include a "super splitter" (that splits the ball into two pieces) and a literal "fireball".

Fielding power ups include a "brick wall" that instantly stops a ball and a "super jump" to catch high line drives or rob home runs.