In organic chemistry, the Malaprade reaction or Malaprade oxidation is a glycol cleavage reaction in which a vicinal diol is oxidized by periodic acid or a periodate salt to give the corresponding carbonyl functional groups.
[1][2] The reaction was first reported by Léon Malaprade in 1928.
[3][4] Amino alcohols are also cleaved.
[5] In terms of mechanism, the reaction is thought to proceed by a cyclic diester of iodine(VII).
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