Mammillaria parkinsonii, also known as owl-eye pincushion or owl-eye cactus, is a species of flowering plant in the family Cactaceae.

It is endemic to Queretaro, Mexico.

Mammillaria parkinsonii is listed as Endangered due to a limited distribution (extent of occurrence ca 2,500 km2), severe fragmentation, a continuing decline due to illegal collection, and degradation of its habitat across its range.

Clarification of the taxonomic status of this species is a research priority.

This Cactaceae article is a stub.