She made her debut in 2011 with the film Mujhse Fraaandship Karoge and was noted for her performance in the Karan Johar movie Student of the Year.

She debuted in Bollywood, portraying the role of the fierce Neha in Mujhse Fraaandship Karoge (2011).

This performance made director Karan Johar notice her talent.

Manasi continues to act in plays and films, on TV, and on the big screen.

She appeared in a web series It's Not That Simple (2018) as Natasha (Nats) aired on Voot with other featured cast members Swara Bhaskar, Purab Kohli and Sumeet Vyas.