Originally a municipality in its own right, it became part of Iloilo City on July 16, 1937, along with the former towns of Arevalo, La Paz, and Molo under Act No.

The former fishponds and salt beds have given way to urban development, paving the way for the emergence of the city's new commercial hub.

Today, Mandurriao stands as a thriving area with a vibrant mix of residential, commercial, and business establishments.

In the 1990s, the Philippine aviation industry liberalized and air travel increased in the country, and problems at Mandurriao Airport began to emerge, prompting the national government as well as the city and provincial government's agreement to a proposal to build the current Iloilo Airport outside of the city.

The transformation of the former airport site into the Iloilo Business Park has attracted significant investment from prominent companies.

The development of the Iloilo Business Park and the surrounding area in Mandurriao has significantly transformed the landscape and economic profile of the district.

It has become a vibrant center for business, commerce, and leisure, attracting both local and foreign investments while contributing to the overall growth and progress of Iloilo City.

[7] Mandurriao is the second-largest district in Iloilo City, covering 13.78 square kilometres (5.32 sq mi).

Mandurriao is bordered by the districts of Jaro to the northeast, La Paz to the east, City Proper to the southeast, Molo to the south, and Arevalo to the southwest.

In March 2019, the Land Transportation Franchising and Regulatory Board announced the opening of a new Premium Point-to-Point Bus Service in Iloilo City with express bus services from Festive Walk Transport Hub in Iloilo Business Park to Iloilo International, Kalibo International, and Caticlan airports in Cabatuan, Kalibo, and Boracay (Caticlan, Malay), respectively.