Manicaragua (Spanish pronunciation: [manikaˈɾaɣwa]) is a municipality and mountain town in the Villa Clara Province of Cuba.

It is located in the Escambray Mountains at the southern part of Villa Clara, bordering the provinces of Cienfuegos to the west and Sancti Spíritus to the east.

Coffee beans from Manicaragua bear a flavorous unparallel nectar, though not known in the Western World due to the economic embargo.

El Hoyo de Manicaragua, once known as the Land of the Best Tobacco in the World, is a small village located in this municipality.

Its popularity faded after the crop was relocated to the western Cuban province of Pinar del Río, where many of the local campesinos were transferred due to their anti-Castro activities.