It heads north, immediately crossing a railroad line and traveling through rural farmland for several kilometers, paralleling the western coastline of Lake Manitoba as it passes the Lakeland community to enter the town of Langruth.

Traveling straight through town along Main Street, it has an intersection with PR 265 before leaving Langruth and winding its way north into the Rural Municipality of Alonsa.

Heading straight through the center of town, it has an intersection with PR 261 (Broadway Road) before leaving Amaranth and winding its way past Harcus and Leifur for several kilometers to the community of Silver Ridge, where PTH 50 makes a sharp left turn to the east at an intersection with PR 278, where it turns away from Lake Manitoba.

It passes through more neighborhoods before coming to an end at an intersection with PTH 5 (Parks Route), with the road continuing west as PR 361.

Running for 7.5 kilometres (4.7 mi), it provides access to the Lakeland boat launch on the Whitemud River, near its mouth on Lake Manitoba.

It is entirely unpaved, with the section between PTH 50 and Road 50W two-lanes wide, with the remaining 0.8 kilometres (0.50 mi) to Lake Manitoba being a narrow one-lane track.

Provincial Road 573 (PR 573) was a 9.8-kilometre-long (6.1 mi) east-west spur of PTH 50 in the northern part of the Municipality of WestLake-Gladstone, connecting it with Hollywood Beach on the western coastline of Lake Manitoba.