PR 243 is one of the southernmost east-west highways in the province, and travels in very close proximity to the Canada - US border.

During the entire route, the highway travels no more than 6 kilometres (4 mi) from the international boundary.

It heads due east as a paved two-lane highway to travel through the community of Reinland, where it makes a couple of sharp turns, meets PR 521 on the border with Rosengart, and enters the Municipality of Rhineland.

The highway now has a short concurrency (overlap) with PTH 30 on the northern edge of Gretna, where it turns to gravel, before traveling past the hamlets of Edenburg and Halbstadt just prior to passing through a short section of the Rural Municipality of Montcalm.

[1][2] Provincial Road 524 (PR 524) is a short 4.5-kilometre-long (2.8 mi) north-south spur of PR 243 in the Municipality of Rhineland, Manitoba, connecting the highway to the hamlet of Blumenort South, located only 0.3 kilometres (0.19 mi) north of the United States border.