[1] In 2013, Santiago won two consecutive stops in the first ever "Select Series" at Street League Skateboarding (SLS) Brazil and Barcelona.

As an amateur, Santiago won 1st place for Best Trick at the Black Box Crossroads Contest amongst professional skateboarders like Nyjah Huston, Chris Cole, Torey Pudwill, and Ryan Sheckler.

In 2012 during an interview with Vice Magazine, Santiago stated: "Lowell ended up building some skate parks, and one happened to be near the Boys' Club where I went.

[5][6] Santiago competed in the 2009 Zoo York's AM Getting Paid Contest in Montreal, Quebec, Canada where he placed 2nd with tricks including kickflip backside crooked grind, laser heel, 360 shuvit lipslide.

[7] Crossroads Early in his career Santiago won 1st place for "Best Trick" in the Black Box Crossroads Best Trick Contest alongside professional skateboarders like Nyjah Huston, Chris Cole, Torey Pudwill, Ryan Sheckler, et al.[8][9][10] Shortly after, Santiago became a professional skateboarder.

The Manny Slays All line has branched out into collaborations with other companies such as Rastaclat, Grizzly Griptape, Famous Stars and Straps, and Eckō Unltd.

[15] As of April 2, 2019, Santiago is sponsored by Fortune Skateboards, Eckō Unltd., Grizzly Griptape, Diamond Supply Co., Krux Trucks, Andale Bearings, Funbox Monthly,, SK8HOP and Black Plague Brewing.

"With his Rookie of the Year winnings from the 2011 Dew Tour, Manny gives back to his friends and teammates in order to best appreciate how skating has affected his life.

What started out as a small trip grew into a full tour equipped with multiple teams, demos and a contest for the kids.

"[4] Santiago and childhood friend and professional skateboarder, Dave Bachinsky spent thirteen-hour days in Puerto Rico repairing a local skate park in preparation for the contest.

"Complete with Puerto Rican dream sequences, J-Kwon annihilation, and super rad homie vibes, this is 9 minutes of two best friends tag-teaming spots and going absolutely hammer-time in the streets.

The third episode of LIVE&LEARN follows Santiago to meet up with professional skateboarder and celebrity, Ryan Sheckler in San Clemente, CA to skate his private warehouse.

The sixth episode, "Bon Voyage Bastien", features Santiago bidding a farewell to friend and professional skateboarder Bastian Salabanzi as he heads home to France.

Shortly after the tooth was extracted, Santiago stated in an interview: I face planted at the Costa Mesa Damn AM last year in November.

Santiago's missing tooth and smile quickly became an easily recognizable trademark for Manny Slays All aka MSA.

Santiago's fan base directly references Manny Slays All aka MSA when chipping or losing teeth in skateboard accidents.