Mano Po stars an all-star cast headed by Maricel Soriano, Richard Gomez, Kris Aquino and Ara Mina.

After taking on menial jobs, Luis invests in the copra industry and with his hard work and ability to cultivate connections with the changing political leadership, builds up a business empire now headed by his eldest grandchild and Richelle's sister, Vera.

Luis and Elisa produce two children: The eldest is Daniel, who begets three daughters: Vera, Juliet and Richelle from his wife Gina, and Jimmy, his son from another woman.

Despite her reputation, Richelle maintains good relations with Juliet, her grandmother Elisa, who she sees as the bravest in the family for her past, and her aunt, Daniel's sister Linda, whose political activism and decision to marry a Filipino who was later forcibly disappeared in the 1980s, led to her being briefly disowned by Luis.

At the hospital, Richelle recovers and gains the respect of her family, including Vera, who expresses regret at not having taken Emerson's advice to reconcile with her sisters before his death.

Vera gives her engagement ring to Richelle as a wedding gift before migrating to Canada, and accepts her identity as a Filipino after years of complaining about anti-Chinese sentiment.