In 1855, a four-story addition on the building's east side was built, in front of the Carlyle House mansion.

B. Porter, after allegations of mistreatment of patients were published in the New-York Tribune and Washington National Republican on February 6, 1862.

[2] Following the surrender of the Confederacy on April 9, 1865, the Mansion House Hospital was returned to the Greens and reopened as a hotel.

[8] Some of the characters are based on real historical figures associated with the hospital, for example the Green family and nurse Mary Phinney von Olnhausen.

[9] Pulitzer Prize-winning novel Night Watch is partially set within a fictionalized version of Mansion House Hospital.