The town began as a crossroads store owned and operated by Woods Pearce.

Near Mantachie on the old Jacinto Road was the largest Chickasaw village in this section of the state.

Mantachie Creek, a south-flowing tributary of the Tombigbee River, runs past the west side of the town.

about 11.6% of families and 9.2% of the population were below the poverty line Mantachie is served by the Itawamba County School District.

The Mustangs field athletic teams in football, cross country, slow pitch and fast pitch softball, basketball, baseball, track, bowling, and archery (the last of which has won state championships from 2014–17).