Van Buren is a ghost town located in Itawamba County, Mississippi.

Once a busy port on the Tombigbee River, Van Buren is today a rural farm community.

Van Buren was located on a high bluff on the river's west bank.

[2] By 1840, Van Buren was the largest town in Itawamba County, and had a busy river port.

[6] The completion of the Mobile and Ohio Railroad west of Van Buren in the late 1850s caused river traffic to diminish;[5] the railway "ruined it and the old site is now under cultivation".