The first building of Roxas High School was situated in Quezon Boulevard near Feati University.

It was established in 1948 and is the first high school to be named after a former president, Manuel Acuña Roxas.

The Main, Vocational, Macaeda and Hizon buildings house the academic subject classes.

On February 22, 2008, President Gloria Macapagal-Arroyo led the groundbreaking for the PHP 220 million 4-storey building to replace the old structure.

Also present in the event were Manila Mayor Alfredo S. Lim, Manila 6th District Rep. Benny Abante and 5th District Rep. Amado Bagatsing and Education Secretary Jesli Lapus.