He lived in Italy, Crete and Lesbos where he translated the works of Boethius and Anselm of Canterbury into Greek,[1] and several Latin liturgical Texts such as the Missa Ambrosiana in Nativitate Domini.
When he was summoned to subscribe to the Tome of Palamas (the official statement of orthodoxy issued in 1351 at the Council of Blachernae), as a result of his anti-Palamite writings, he refused to do and was sanctioned.
He fled to Pera, the Genoese quarter of Constantinople, in order to avoid prosecution.
In 1396 he wrote a letter reproaching Manuel II, which the Emperor answered with bitterness.
[3] Kalekas returned to Constantinople in 1403 with the emperor Manuel II Palaiologos, but to his surprise, was not given a warm reception by his old friends.