The Manyeleti Game Reserve is situated in the east of the Mpumalanga province of South Africa.

The game reserve is managed by the Mpumalanga Provincial Government and is over 22,750 ha in area.

Manyeleti lies directly adjacent to the Kruger National Park (without fences), with the Sabi Sand Game Reserve to its south and the Timbavati Game Reserve to its northwest.

During the Apartheid years, the central government designated Manyeleti as a game reserve for exclusive use by the Bantu's of the country, hoping that this arrangement would satisfy black South Africans' aspirations to a Game Reserve of their own.

[1] The Tsonga people, who occupied the land before colonization, were given visiting rights to this area.