Patiño's first contacts with television, a medium through which she has reached a certain popularity in Spain, began on the Canal Sur program Ven con nosotros (2001),[6] which was followed by the Antena 3 magazine Sabor a verano (2002), presented by Inés Ballester.

[7] After her stint on Jordi González's late-night show Abierto al anochecer (2002), she appeared on what was one of the most followed programs of its type, Sabor a ti [es] (2002–2004), together with Ana Rosa Quintana.

On 15 October 2011, once DEC was canceled, María Patiño held an interview for La noria [es] on Telecinco, speaking with Bárbara Rey, with whom she had a great dispute in 2007.

[12] In 2015 María Patiño debuted as an actress with the short film La cara del diablo, appearing alongside her romantic partner Ricardo Rodríguez Olivares.

[13] Previously she had had minor roles in 2011's Torrente 4: Lethal Crisis, where she made a cameo as a tabloid reporter covering an event, and in 2004, when she played herself in the eighth episode of the third season of Aquí no hay quien viva, where a resident of the building attends the set of Dónde estás corazón.