In 52 BC he was elected consul, together with Servius Sulpicius Rufus, for the following year.
During his consulship, Marcellus proved himself to be a zealous partisan of Pompey and the optimates, and urged the Senate to extreme measures against Julius Caesar, managing to establish that the subject of recalling Caesar should be discussed on 1 March of the following year.
He also considered the lex Vatinia invalid, removing Roman citizenship from citizens of Comum, and caused a senator of Comum, who happened to be in Rome, to be scourged, a punishment Roman citizens were exempted from under the Lex Porcia.
[2] Upon the start of Caesar's civil war, Marcellus fled Rome with the optimates and joined the Republican army in Epirus.
His cousin Gaius Claudius Marcellus petitioned the dictator for clemency, as did Cicero in his Pro Marcello.