In 2010, it was named in honor of the Spanish actress Margarita Xirgu who developed part of her career in Uruguay.
[3] Its first home was the east wing of the Solís Theatre in Montevideo, a place it shared with the Comedia Nacional.
[8] Starting in 2001 and in the following years, the school moved several times, until settling in its current home, on Mercedes Street in the Cordón neighborhood.
[11] However, a year later, it was renamed the Margarita Xirgu Multidisciplinary School of Dramatic Art, again retaining the acronym.
[13] In January 2024, the purchase of the headquarters building of the Central Israelite Committee of Uruguay and the Synagogue of the Jewish Community to house the school facilities was confirmed.