Her father Joseph La Flesche was the head chief of the Omaha Tribe.

[4] In 1888 she married Charles Felix Picott who died of tuberculosis a few years after their marriage.

[3][4] La Flesche Diddock taught for many years at the Omaha Agency government school in Nebraska.

At the time the OIA directed field matrons to instruct Native American women about Euro-American culture and traditions with the aim of accelerating the adoption of Euro-American culture within the community.

[1] La Flesche Diddock remained active in the Omaha Tribe including serving on the election board after the passage of the 19th amendment and working to bring libraries to the area.