Mariano Smiriglio (1561–1636) was a Sicilian architect, painter and decorator, active in a Mannerist-Sicilian Baroque style in his native Palermo.

He was born in Palermo, and started as a painter at the school of Filippo Paladini, then he worked as an architect.

In this capacity, he collaborated with Giulio Lasso for the construction of the Quattro Canti.

Smiriglio died in 1636 in Palermo, and was buried in the Church of the Madonna del Soccorso.

This article about an Italian painter born in the 14th century is a stub.