Marie was born at the royal residence of the Château de Vincennes as the sixth child and fourth daughter of Charles VI of France (1368–1422) and his wife, Isabeau of Bavaria (c. 1370–1435).

Isabeau decided to dedicate Marie to the service of God, possibly because she saw her husband's apparent madness as divine punishment.

[3] She was greeted "joyously and tenderly" by the seven-year-old princess, whose lodgings were befitting for her rank.

She refused to do this, saying that only the king, who was at the time mentally unstable, had the power to force her to marry.

Marie died of bubonic plague during the pandemic known as the Black Death on 19 August 1438, a few days short of her forty-fifth birthday and was buried at the convent.