In 846 AD, Bovillae – until then the largest settlement – was destroyed by the Arabs, and the population moved to the more easily defendable area of Ferentum, which was fortified under the new name of Marinum.

Marino hosted famous historical figures, from Charles VIII of France to Alfonso II d'Este and many others.

In 1571, Marino's people welcomed Marcantonio Colonna, a protagonist of the Battle of Lepanto, with a triumph, remembered yearly by a festival.

On 2 February 1944, during World War II, Marino was heavily bombed by USAAF B-25 aircraft from the US XII Air Force.

In the Due Santi district, there is the Roman campus of the University of Dallas, which opened in 1994 and is used by its students for year-round academic programs.