Active since 2000, she is currently signed to Sacred Bones Records and Bella Union, and released her ninth full-length studio album, The Path of the Clouds, in October 2021.

Her voice was described by Pitchfork as one "you would follow straight into Hades", and also "textured and angelic, with just a hint of pain captured within her iridescent falsetto".

[6] The Boston Globe said, "She has a voice that, in mythological times, could have lured men to their deaths at sea, an intoxicating soprano drenched in gauzy reverb that hits bell-clear heights, lingers, and tapers off like rings of smoke".

[13] Nadler went on some of her first tours with acts such as the late American primitive guitarist Jack Rose and the drone metal band Earth.

[10] In early 2010, Nadler contributed vocals on Portal of Sorrow, the final album by black metal project Xasthur.

[22] The album was positively received by Pitchfork, which gave it 8.1 out of 10,[23] and it was called "a stellar collection of sullen melodies and lovelorn anecdotes akin to those of Joni Mitchell".

[50] During this period, Nadler directed and animated music videos for Strangers tracks "Janie in Love"[51] and "All the Colors of the Dark",[52] as well as "Blood and Tears",[53] a Danzig cover she had self-released as a digital-only single for Halloween 2015.

[55] After touring Europe and North America promoting Strangers, Nadler guested on the Lawrence Rothman album The Book of Law (2017),[56] and on Ojalá (2017), the debut album by Lost Horizons, a duo consisting of Simon Raymonde (Cocteau Twins) and Richie Thomas (Dif Juz, the Jesus and Mary Chain).

[62] Rolling Stone wrote that, in contrast to the 2014 break-up album July, For My Crimes, "seems to touch instead on the daily realities of making a relationship work, the epilogue to a happily-ever-after love story when real life kicks in".

The album's first video, "Blue Vapor", was directed by Thomas McMahan, who "utilizes various experimental and mixed media animation techniques, merging the mood and imagery of the song with hallucinatory visuals..."[65] Nadler's wardrobe in the video for "Blue Vapor" was created and put together by New York-based costume designer and stylist Jenni Hensler, who also styled Nadler's Pitchfork.tv performance clip for the song "Dissolve.

[69] The album received positive reviews, earning a 8/10 score from Soundblab,[70] 8/10 from PopMatters,[71] 7/10 from Atwood Magazine,[72] 7/10 from Earbuddy,[73] 3.5/5 from The Thin Air[74] and a 4.5/5 from Cryptic Rock.

"[78] On December 6, 2019, Nadler and Brodsky released two cover songs on Bandcamp that were not included on the Droneflower album: "In the air tonight" by Phil Collins and "More than words" by Extreme.

[79] Nadler's figurative and sonic work again converged at the Grauzone Festival in The Hague in February 2020 with a stage performance and simultaneous exhibition of self-portrait paintings.

"[86] A review from the magazine UNCUT notes that, "[e]scape is a central theme of the album, and several songs recall historical cases of mysterious disappearances, but infused with personal experience, blurring the line between fact and fiction.

[88] Various guests make an appearance on The Path of the Clouds including harpist Mary Lattimore and former Cocteau Twins bassist Simon Raymonde.

Emma Ruth Rundle contributes a guitar solo to "Turned into Air" and Amber Webber of Black Mountain provides backing vocals on "Elegy".

NME gave the album a positive review, writing, "This is a departure for Nadler in a number of ways, with more sophisticated production, unusual storytelling, and a firm look ahead to her future as an artist (more piano, more power vocally).

[92] Other reviewers were even more positive, with All Music Guide (4 ½ stars) praising the "epic, aching songs, which refuse to keep tragedy at arm's length"[93] and Sputnikmusic (superb: 4.5) noting that it "sounds so lush, sweeping, and powerful that all the subtle, intricate melodies are merely the cherry on top.

"[94] In its five-star "essential" review, Contact Music called the album "exquisitely crafted and utterly beguiling" and recommended that, "The Path of the Clouds … should be listened to, uninterrupted, in its entirety.