In 2001, he rode Todd Pletcher's Balto Star to victories in the Arkansas Derby and Lane's End Stakes.
In 2002, he set a course record at Churchill Downs on board Island Echo winning a five-furlong turf allowance sprint in 55.91 seconds for trainer Bill Mott.
That same year, he was voted the esteemed George Woolf Memorial Jockey Award by his peers in part for his assistance to the victims of Hurricane Katrina.
In 2006, he won the Swale Stakes on Sharp Humor, and ran second with him by a half length in the Florida Derby to Barbaro.
Guidry and Sharp Humor nearly held off the eventual Kentucky Derby winner in a thrilling stretch duel.
He picked up his riding in the spring of 2012 full-time at the Louisiana Downs spring/summer meet, where he commanded a 24 percent winning rate.
Mark Guidry resides in New Orleans, Louisiana, with his wife Tina, and children Marcus, Mecus and Fallon.