[2] Tatulli grew up in Willingboro Township, New Jersey and started drawing in his youth, publishing his first cartoons in the pages of the Burlington County Times.

"[4] In a 2014 interview with L'Idea, Tatulli cited Berkeley Breathed 's Bloom County, Bill Watterson's Calvin and Hobbes, Garry Trudeau's Doonesbury and the ensemble at Mad magazine as being the cartoons that most influenced his career and style as a cartoonist.

[6] Liō, which has been published since May 2006, is a "sweetly dark" pantomime cartoon without dialogue that was inspired by Tatulli's love of the horror movies he watched while growing up as a child in the 1970s.

[4] He has won three Emmy Awards for the production design he did for the cable reality television series Trading Spaces and A Wedding Story.

[citation needed] In late 2019, Tatulli decided to retire from drawing “Heart of the City” after 22 years, choosing instead to focus on "Liō" and creating graphic novels.