She also served as Commissioner on Narcotic Drugs at the Federal Ministry of Health in the government of Chancellor Angela Merkel from 2014 until 2019.

In addition to her committee assignments, Mortler was a member of the German-Maltese and German-Hungarian Parliamentary Friendship Group since February 2010.

[2] In the negotiations to form a coalition government following the 2009 federal elections, Mortler was part of the working group on the environment, agriculture and consumer protection, led by Ilse Aigner and Michael Kauch.

[3] In addition to her parliamentary work, Mortler also served as Commissioner on Narcotic Drugs at the Federal Ministry of Health in the government of Chancellor Angela Merkel from 2014 until 2019; she was succeeded by Daniela Ludwig.

In the negotiations to form a coalition government under the Merkel's leadership following the 2017 federal elections, she was part of the working group on municipalities and rural areas, led by Reiner Haseloff, Kurt Gribl and Michael Groschek.

[7] In December 2023, Mortler announced that she would not stand in the 2024 elections but instead resign from active politics by the end of the parliamentary term.

The German Cancer Aid has responded with praise to Mortler's initiative to ban tobacco advertising in Germany.

[12] She was criticized for incompetence, an inappropriate qualification in "rural home economics" (German: Meisterin der Ländlichen Hauswirtschaft)[2][13] for the job, having a double standard (because of her promotion of alcohol consumption[14][15][16][17]) and a preoccupation concerning suggestions about cannabis legalization.