The Marromeu Game Reserve is a protected swath of 1,500 square kilometres (580 sq mi) of floodplain in the Zambezi, the only such area along the river.

The African elephant, Lichtenstein's hartebeest, sable antelope, eland, burchell's zebra, hippopotamus, waterbuck, and reedbuck are all found there.

Several species of water birds, including Great White and Pink-backed Pelicans, Yellow-billed and African Open-billed Storks, Glossy Ibis, and White-breasted Cormorants, all have substantial breeding colonies within the park, making it Mozambique's wetland with the highest water bird population density.

In addition to providing a safe haven for migratory birds, the marsh serves as a breeding ground for 120 endangered Wattled Crane pairs.

[2] In 2022, the IPCC Sixth Assessment Report included Marromeu Game Reserve in the list of African natural heritage sites which would be threatened by flooding and coastal erosion by the end of the century, but only if climate change followed RCP 8.5, which is the scenario of high and continually increasing greenhouse gas emissions associated with the warming of over 4 °C.,[3] and is no longer considered very likely.