Playing for the Seahawks from 2010 to 2015, Lynch was voted to four consecutive Pro Bowls, made one first-team All-Pro selection, and twice led the league in rushing touchdowns.

In the spring, he joined the Cal Track & Field team, and he competed in the 60-meter dash, recording a personal-best time of 6.98 seconds at the 2006 MPSF Championships.

[43] He later called the run his favorite career highlight, after which Lynch spontaneously drove around the football field in an injury cart, pretending to ghost ride.

[46] In his final game for Cal, Lynch ran for 111 yards and two touchdowns in the 45–10 victory over Texas A&M in the Pacific Life Holiday Bowl on December 28, 2006.

Lynch's success on the ground was instrumental in keeping the touted Cincinnati offense on the sidelines, as he rushed 29 times for 153 yards, including a 56-yard touchdown run.

[60] He returned to play on December 9 for the Bills' second game against the Miami Dolphins that season, rushing for 107 yards and fumbling for the first time in his NFL career.

[75] He was able to stay healthy until injuring his shoulder in the second half of a Bills victory on December 21 against the Denver Broncos, during which he rushed for his eighth touchdown of the season.

[79] Following his guilty plea on misdemeanor weapons charges during the 2009 off-season, Lynch met with NFL Commissioner Roger Goodell for a disciplinary hearing.

[102] On January 24, 2012, Lynch was added to the NFC Pro Bowl roster to replace San Francisco 49ers running back Frank Gore.

[146] Four days later, Lynch was fined $11,050 by the NFL for his celebration of the score; falling back while extending the ball behind his head and grabbing his crotch.

[152] Lynch made headlines at Super Bowl XLIX Media Day on January 27, 2015, when he held a five-minute press conference, only answering "I'm just here so I won't get fined" to every question.

[159] Lynch struggled to pile up yardage early in the season but starred in Week 7 in a 20–3 win over the rival San Francisco 49ers, against whom he racked up 122 yards and a touchdown on 27 carries.

[162] Ahead of the Seahawks Wild Card Round matchup against the Minnesota Vikings, Lynch was anticipated to make his return, but decided to stay behind in Seattle, stating that he felt that he could not play.

[165] On February 7, 2016, the day of Super Bowl 50, Lynch announced his retirement via Twitter by posting a picture of his football cleats hanging from a telephone wire.

[168] In early April 2017, after sitting out the 2016 season, it was reported Lynch had agreed to terms with his hometown Oakland Raiders and that the Seahawks, who retained his rights even after retirement, would trade him.

[184] He recorded a rushing touchdown in the first three games of the season against the Los Angeles Rams, Denver Broncos, and Miami Dolphins, all losses for the Raiders.

[191] Lynch returned to the NFL during the final week of the 2019 regular season, signing with the Seahawks alongside former teammate Robert Turbin on December 23, 2019, after Seattle lost three running backs to injury.

[194] During the Seahawks' 17–9 win over the Philadelphia Eagles in the Wild Card Round of the playoffs, Lynch broke a tackle to score a five-yard, first half touchdown.

"[198] In media ahead of the 2020 NFL Scouting Combine, Seahawks head coach Pete Carroll was also asked about Lynch returning and said "We'll see.

[243][244] On September 19, 2017, Lynch launched his own ad-supported Beast Mobile cellphone service that allows subscribers to pay their phone bill by engaging in ads and offers.

[245] In November 2018, Lynch and Richard Sherman were announced as the first two team owners in a proposed Fan Controlled Football League, a concept based on Project Fanchise's use of a mobile app for fans to call plays for the team that they had initiated with the Salt Lake Screaming Eagles of the Indoor Football League (IFL) a year earlier.

[246] The league was delayed and eventually played its first game, rebranded as just Fan Controlled Football (FCF), in February 2021 with Lynch as one of three owners of a team called the Beasts.

When the Seahawks defensive coordinator Ken Norton Jr's father died, Lynch was the only member of the organization who went to console him at the airport.

[260] After Lynch was shown eating the candy during a nationally televised game on December 5, 2011, Mars offered him a two-year supply of Skittles and a custom dispenser for his locker.

[266][267] The company distributes blunts to dispensaries throughout the Bay Area, with a portion of the proceeds going to Last Prisoner Project, a drug policy reform group.

Lynch re-appeared on the show prior to Super Bowl LI along with Gronkowski, Tom Brady, LeGarrette Blount, and Dwight Freeney playing the game For Honor.

The show references his reluctance to talk to the press during his NFL days, and Detective Rosa Diaz says of Lynch, "There are some vaults you just can't open."

[300] Lynch appeared as himself alongside Will Arnett in an episode of Murderville, a comedic murder-mystery streaming television series released by Netflix in February 2022.

[303][304] In December 2023, Lynch appeared on Lego Masters second installment of its "Celebrity Holiday Bricktacular", teaming up with contestant Dave Guedes.

[306] In July 2024, Lynch began co-hosting the Politickin’ podcast alongside California governor Gavin Newsom and sports agent Doug Hendrickson.