The highway runs 15.23 miles (24.51 km) from Spider Web Road near Centreville east to MD 312 in Bridgetown.

The first sections of modern MD 304 were improved in the 1910s, but much of the highway from Centreville to Ruthsburg was constructed from the mid-1930s to the early 1940s.

The highway heads east as two-lane undivided Corsica Neck Road past the historic home Lexon and crosses Earle Creek.

MD 304 crosses the Old Mill Stream branch of the Corsica River to enter the town of Centreville, where most of the highway is municipally maintained.

Westbound MD 304 traffic follows Broadway one block to the north to head toward the west end of town.

MD 304 leaves the town of Centreville as it passes southwest of Queen Anne's County High School.

The route continues east past the historic Thomas House and Hawkins Pharsalia on either side of the road's bridge across German Branch.

Caroline County built the two-span reinforced concrete Mason Branch bridge and a 9-foot-wide (2.7 m) shell road east through Bridgetown in 1914.

[4] Queen Anne's County paved Water Street as a 14-foot-wide (4.3 m) concrete road from west of Commerce Street to the Centreville Branch of the Philadelphia, Baltimore and Washington Railroad and built a 9-foot-wide (2.7 m) shell road from the railroad to about 2 miles (3.2 km) east of downtown between 1915 and 1921.

A groundbreaking ceremony was held on September 23, 2014, with several Queen Anne's County commissioners and representatives from state government in attendance.