Known for most of its length as Central Avenue, the highway runs 1.07 miles (1.72 km) from Southern Avenue at the District of Columbia boundary in Capitol Heights east to MD 214 in Seat Pleasant.

MD 332 heads east as a two-lane undivided road through the town of Capitol Heights.

In the center of town, the highway intersects Larchmont Avenue and Chamber Avenue; the latter leads north to the Capitol Heights station on the Washington Metro's Blue and Silver lines.

MD 332 continues as Old Central Avenue and becomes one-way with one eastbound lane just before merging with eastbound MD 214 (Central Avenue) on the southern edge of the city of Seat Pleasant.

[6] MD 214 was relocated from Southern Avenue to Seat Pleasant as an extension of East Capitol Street in 1969.