The state highway runs 9.79 miles (15.76 km) from the terminal of the seasonal Oxford–Bellevue Ferry in Oxford north to Washington Street in Easton within southwestern Talbot County.

In Easton, MD 333 was assigned to the southern part of Washington Street between 1948 and 1959 after U.S. Route 213 (US 213, later US 50) bypassed the town.

MD 333 begins at the Oxford terminal of the seasonal Oxford–Bellevue Ferry across the Tred Avon River to Bellevue.

The state highway heads southeast through the town as two-lane undivided Morris Street.

The state highway heads east through farmland, beginning a curve to the northeast shortly before Almshouse Road.