Known for most of its length as Laurel Road, the state highway runs 1.39 miles (2.24 km) from Main Street just west of MD 313 in Sharptown east to the Delaware state line, where the highway continues as Delaware Route 24 (DE 24).

The state highway heads southeast on two-lane undivided Main Street, where it immediately encounters MD 313 (Sharptown Road).

After passing Santo Domingo Road, the route turns east and reaches its eastern terminus at the Delaware state line.

[3] The first segment of highway to be completed was from the Delaware state line to Santo Domingo Road.

[6] The portion of MD 348 between State Street and Eagles Avenue was transferred to local maintenance by 1999.