Known as Accokeek Road, the highway runs 8.16 miles (13.13 km) from MD 210 in Accokeek east to Brandywine Road just east of MD 5 in Brandywine.

Livingston Road continues west as unsigned MD 810J a short distance before becoming a county highway.

The highway turns north at its three-way intersection with Bealle Hill Road and turns east again at its second T junction with Bealle Hill Road.

MD 373 continues east through the hamlet of Danville and curves around Lake Ruth, an impoundment of Burch Branch of Piscataway Creek.

[1][2] The portion of MD 373 that follows Livingston Road was originally part of MD 224, which followed Livingston Road from Mason Springs in Charles County north to Washington.