The state highway heads southeast as two-lane undivided Burbage Crossing Road.

MD 374 crosses the Pocomoke River and enters Worcester County, where the highway's name changes to Libertytown Road.

The state highway curves northeast and passes through Libertytown, where the highway intersects Purnell Crossing Road and Ironshire Station Road, then crosses Libertytown Branch.

After passing Bay Club Golf Course, MD 374 enters Berlin, where the name of the highway changes to Broad Street.

The state highway crosses the Snow Hill Line of the Maryland and Delaware Railroad and enters the Berlin Commercial District.