The highway travels through mostly rural areas of farms and woods as well as the communities of Hopewell, Marion Station, and Kingston.

MD 413 was relocated starting in the late 1930s to a new alignment parallel to the Eastern Shore Railroad line that made Crisfield the "Seafood Capital of the World."

[1][2] It begins on a four-lane divided boulevard, and is known as West Main Street, fronting local businesses in the downtown area.

On a gentle curve, Chesapeake Avenue intersects the northbound carriageway, providing access to the southern beginning of MD 667.

[2] Before leaving the city, the route intersects MD 460, also known as Hall Highway, immediately accessible only from the southbound carriageway.

Access to that route from northbound MD 413 is given by Wynfall Avenue, which the road intersects farther south.

After intersecting Silver Lane, the left turn lane ends, and MD 413 becomes a rural, two-lane undivided highway with full shoulders, exiting Crisfield's corporate limits just north of the Sherwin–Williams (former Rubberset) entrance and continuing past the old site of Carvel Hall Cutlery.

[1] Beyond Kingston, the route crosses the Big Annemessex River and travels past a tree farm.

MD 413 heads through some woods and crosses the Back Creek of the Manokin River before coming to end at an intersection with US 13.

[8] The state road was paved from the eastern city limits of Crisfield (the present western terminus of MD 667) to Hopewell and from Westover to Kingston in 1913.

[11][12] Starting in the mid-1930s, MD 413 was relocated to an alignment paralleling the Crisfield Secondary Branch of the Pennsylvania Railroad.

[20][21] North of the Main Street portion of the divided highway, the railroad track separated the two directions of MD 413: Maryland Avenue formed the southbound lanes while Richardson Avenue was brought into the state highway system to comprise the northbound lanes.

The two directions of MD 413 were divided by an operating railroad track until the Crisfield Secondary Branch was abandoned with the formation of Conrail in 1976.