Known as Jacksonville Road, the state highway runs 1.13 miles (1.82 km) from MD 413 in Crisfield north to the end of state maintenance near Alfred J. Lawson Road.

MD 358 heads north as two-lane undivided Jacksonville Road.

Jacksonville Road continues north as a county highway toward Crisfield Municipal Airport.

[5][7] The state highway along Somerset Avenue was widened from Main Street to MD 413 around 1954.

[9] The state highway was relocated at Box Iron Road to eliminate two sharp curves between 1988 and 1999.