MD 424 heads northwest out of Davidsonville as a two-lane undivided road and passes to the east of the historic homes Mount Airy and Indian Range, which are located along Mount Airy Road.

A park and ride lot serving MTA Maryland commuter buses is located at the southeast corner of this interchange.

The highway passes by the historic home Linthicum Walks and along the northeastern edge of the planned community.

[4][5][6] By 1934, the Maryland State Roads Commission recommended the highway be expanded to a width of 20 feet (6.1 m) for its whole length.

[8] The state highway's interchange with the Annapolis–Washington Expressway, which became part of US 50, was constructed between 1950 and 1952 concurrent with the portion of the freeway between Bowie and Parole.

[16] MD 424 was expanded to a divided highway when a pair of new bridges were constructed at its interchange with US 50 and US 301 in 1994.