MD 425 connects Nanjemoy and Ironsides with Pisgah and Mason Springs in western Charles County.

The state highway heads northeast as two-lane undivided Ironsides Road through a forested area, passing Baptist Church Road and crosses a branch of Hill Top Fork of Nanjemoy Creek.

The state highway continues north as Mason Springs Road, crossing Jane Berrys Run.

[1][2] The first section of MD 425 was constructed as a gravel road south 2 miles (3.2 km) from Mason Springs in 1930.

Also in 1933, 1 mile (1.6 km) of gravel road was constructed from the Nanjemoy end.