Known as Friendship Road, the state highway runs 1.64 miles (2.64 km) from U.S. Route 50 (US 50) near Berlin north to MD 575 in Friendship in northern Worcester County.

MD 452 begins at an intersection with US 50 (Ocean Gateway) to the northeast of Berlin.

Seahawk Road continues south from the intersection, providing access to Stephen Decatur High School and Stephen Decatur Middle School.

The state highway heads north as a two-lane undivided road through a mix of farms and residences, crossing Taylorville Creek.

[3][4] The state highway was extended south a short distance to its present terminus when the US 50 divided highway was completed in 1950.