MD 480 was rerouted in both towns in the early 1950s before being extended west to Hillsboro in the late 1950s.

According to Backroads and Byways of Chesapeake Bay, Drives, Day Trips & Weekend Excursions, Leslie Atkins.

MD 480 follows St. Joan's Path which was originally an ancient Native Americans trail used by both Choptank and Naticoke tribes.

The two state highways continue northeast, with MD 776 (Sunset Boulevard) splitting to the north immediately before the road enters the town limits of Ridgely, where its name temporarily changes to Sixth Street and the highway passes south of Martin Sutton Memorial Park.

[3][4][5] The state highway originally followed Central Avenue in Ridgely south from MD 312, then turned east onto Sixth Street toward Greensboro.