MD 506 provides access to Battle Creek Cypress Swamp.

The state highway was constructed from MD 2 to the swamp in the early 1930s and extended to Bowens in the late 1950s.

Sixes Road continues west as a county highway toward the Patuxent River.

MD 506 heads east as a two-lane undivided road that passes through a forested area with scattered residences.

The sanctuary visitor center is located on Grays Road, which intersects MD 506 just east of Battle Creek.