MD 611 is named for Stephen Decatur, the U.S. naval officer of the early 19th century who was born in nearby Berlin.

A ferry crossed Sinepuxent Bay to Assateague Island from the southern end of the county highway that continued south from Lewis Corner until MD 611 was extended across the Verrazano Bridge in the mid-1960s.

Upon reaching Sinepuxent Neck, the state highway passes the Assateague Island National Seashore visitor center on the southbound side before it curves to the northeast and intersects South Point Road, which leads to Rum Pointe Golf Course and the Ocean City Golf and Yacht Club.

In Lewis Corner, the state highway intersects the eastern terminus of MD 376 (Assateague Road), and passes Frontier Town Amusement Park and another historic home, Fassitt House.

[7][8] MD 611 was extended south from Lewis Corner to the eastern end of the Verrazano Bridge in 1967.