MD 376 connects Berlin with communities on the Sinepuxent Neck and, in conjunction with MD 611, connects Berlin with Assateague Island National Seashore.

The state highway was constructed from Berlin in the second half of the 1920s and the early 1930s.

After intersecting the southern end of MD 377 (Williams Street), the state highway heads east as two-lane undivided Bay Street east to U.S. Route 113 (US 113, Worcester Highway) and leaves the town of Berlin upon traversing Hudson Branch.

[1][2] The section of MD 376 east of US 113 provides access, along with MD 611, to the Maryland section of Assateague Island for traffic coming from US 113 from points north and US 50 from points west.

[3] MD 376 was paved from the Berlin town line to just east of Trappe Creek in 1924.