Crab Island Road heads south toward the Manokin River, while Oriole Back Road heads northwest toward an intersection with MD 363 at Monie.

MD 627 heads east as a two-lane undivided road through the village and makes a sharp turn to the south where Jerusalem Road heads north.

The state highway curves east through forest.

After passing Locust Point Road, which leads south to the Manokin Historic District, MD 627 veers northeast through farmland to its eastern terminus at MD 363 (Deal Island Road).

[3] The highway was brought into the state system and designated MD 627 in 1938.