The state highway heads east into the unincorporated village of Eckhart Mines as a winding two-lane undivided road.

[1][2] MD 743 is the original alignment of US 40 and, before that, the National Road through Eckhart Mines.

[4][5] MD 743 was designated through Eckhart Mines shortly after the US 40 (now US 40 Alternate) bypass of the village was completed in 1950.

[6][7] MD 743 originally extended west to US 40, meeting the highway on a tangent in front of Beall High School at the city limit of Frostburg.

[7] The western end of the state highway was truncated when MD 36 was moved to its present alignment between Midland and Frostburg in 1972.