MD 193 was extended east and south from Greenbelt over the length of Glenn Dale Road to just north of U.S. Route 50 (US 50) in the mid-1960s.

The two-lane undivided state highway heads west, passes through a gentle S-curve to the south, then crosses Lottsford Branch and veers north.

The state highway continues north across the remains of the Glenn Dale Hospital and intersects the Washington, Baltimore and Annapolis Trail.

[5] That same year, construction began on modern US 50 (John Hanson Highway) at the southern end of Glenn Dale Road.

[7] After the US 50 freeway was constructed, Glenn Dale Road was relocated to head due east from Lottsford Branch to MD 556.