In central Prince George's County, MD 193 is the main north–south highway connecting Glenn Dale and Greater Upper Marlboro with the affluent suburbs of Woodmore and Kettering.

After leaving the town limits of Kensington, MD 193 passes through a mix of apartment complexes and single family homes.

MD 193 splits into a one-way pair upon entering the Four Corners commercial area, where the highway intersects U.S. Route 29 (US 29) and passes Montgomery Blair High School.

After crossing the Capital Beltway, MD 193 continues south through residential suburban areas of Silver Spring, intersecting East Franklin Avenue.

After meeting MD 320 and passing Quebec Terrace Park, the state highway turns southeast and enters an area of garden apartments and duplexes.

[1][3] MD 193 continues east into Langley Park, an area with multiple shopping centers, garden apartments, and heavy pedestrian cross-traffic.

After passing Lane Manor Recreation Center, the state highway leaves the commercial area and crosses Northwest Branch.

After turning east again, MD 193 intersects Paint Branch Drive, which serves the Xfinity Center arena.

Both directions of MD 193 access the southbound parkway via Southway, which heads north into the Greenbelt Historic District.

Beyond Goddard, MD 193 heads north of DuVal High School before it crosses Good Luck Road.

MD 193 passes Watkins Regional Park and First Baptist Church of Glenarden before encountering Oak Grove Drive at a roundabout.

From there, the state highway turns southwest and meets its eastern terminus at MD 202 (Largo Road) at the boundary between the census-designated places of Kettering and Brock Hall.

[4] The Connecticut Avenue segment is now MD 185; that portion's history is covered in more detail in the Maryland Route 185 article.

[7] The roads over which MD 193 would later be extended east consisted of three state highways: The four-lane divided bypass of the University of Maryland was started by 1955 and completed in 1956.

[19] Finally, Watkins Park Drive was built in 1988 on a new alignment, replacing Enterprise Road south of MD 214.